Across TCGA cell cohorts, HLA-DRB3 protein abundance is significantly associated with the RNA expression of many other genes, with 221 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HLA-DRB3-associated genes across cancer lineages are SLC30A4, RNFT1, and ASPHD1. Each is linked with HLA-DRB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HLA-DRB3-to-partner and partner-to-HLA-DRB3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRB3→partner) and Y-score (partner→HLA-DRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC30A4 →	-1.221	-2.299	<.001	<.001	3	2
BLOOD_Lymphoma	RNFT1 →	-1.671	-3.006	<.001	<.001	3	2
BLOOD_Leukemia	ASPHD1 →	-0.642	-2.911	.006	.008	3	2
BLOOD_Leukemia	HLA-DOA →	+3.386	+2.298	.007	.002	2	3
BLOOD_Lymphoma	VAPA →	-0.725	-2.345	.005	<.001	3	1
BLOOD_Lymphoma	SETD6 →	-1.343	-2.189	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 221 associations by consensus.

Exploration

HLA-DRB3 survival (RNA) · tumor vs normal (RNA) · all HLA-DRB3 data types