Across TCGA patient cohorts, HLA-DRB1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,559 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DRB1-associated genes across cancer lineages are CIITA, CD74, and HLA-DQA1. Each is linked with HLA-DRB1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-DRB1-to-partner and partner-to-HLA-DRB1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRB1→partner) and Y-score (partner→HLA-DRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CIITA →	+1.042	+0.493	<.001	<.001	3	10
OV	CD74 →	+1.266	+0.578	<.001	<.001	3	10
OV	HLA-DQA1 →	+1.472	+0.433	<.001	<.001	3	10
OV	HLA-DOA →	+1.360	+0.413	<.001	<.001	3	9
OV	HLA-DMA →	+1.058	+0.493	<.001	<.001	3	9
GBM	HLA-DQB1-AS1 →	+1.346	+1.028	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,559 associations by consensus.

Exploration

HLA-DRB1 survival (RNA) · tumor vs normal (RNA) · all HLA-DRB1 data types