Across TCGA patient cohorts, HLA-DRA mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-DRA-associated genes across cancer lineages are Myosin-IIa_pS1943, Notch1, and p27. Each is linked with HLA-DRA in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DRA-to-partner and partner-to-HLA-DRA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRA→partner) and Y-score (partner→HLA-DRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.362	+3.013	.002	.019	3	1
UCEC	Notch1 →	+0.279	+3.000	<.001	.037	3	1
UCEC	p27 →	-0.269	-3.000	.033	.037	3	1
UCEC	p62 Lck ligand →	+0.618	+3.009	<.001	.019	3	1
UCEC	Paxillin →	+0.382	+3.000	.010	.037	3	1
UCEC	TFRC →	+0.680	+3.000	.026	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

HLA-DRA survival (RNA) · tumor vs normal (RNA) · all HLA-DRA data types