Across TCGA cell cohorts, HLA-DRA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,185 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HLA-DRA-associated GO terms across cancer lineages are Dendritic cell antigen processing and presentation, MHC protein complex assembly, and Peptide antigen assembly with MHC protein complex. Each is linked with HLA-DRA in more than 17 cancer types. Because this analysis shows association rather than direction, both HLA-DRA-to-partner and partner-to-HLA-DRA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRA→partner) and Y-score (partner→HLA-DRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Dendritic cell antigen processing and presentation →	+1.843	+7.490	<.001	<.001	3	18
CNS	MHC protein complex assembly →	-0.234	-2.310	<.001	<.001	3	15
CNS	Peptide antigen assembly with MHC protein complex →	-0.234	-2.310	<.001	<.001	3	15
LUNG_NSCLC_LUSC	MHC class II protein complex assembly →	-0.440	-1.967	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Peptide antigen assembly with MHC class II protein complex →	-0.440	-1.967	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Positive regulation of dendritic cell antigen processing and presentation →	+1.907	+3.255	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,185 associations by consensus.

Exploration

HLA-DRA survival (RNA) · tumor vs normal (RNA) · all HLA-DRA data types