HLA-DQB2

Across TCGA pan-cancer cohorts, HLA-DQB2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HLA-DQB2 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HLA-DQB2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HLA-DQB2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where HLA-DQB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.802	0.472	<.001	34	view →
PDAC	OS	Tertile	All	0.961	0.745	.002	24	view →
HNSC	OS	Median	All	0.795	0.928	.016	18	view →
CCRCC	OS	Tertile	All	1.000	0.859	.017	7	view →
GBM	OS	Median	All	0.444	0.776	.033	4	view →
LSCC	DFS	Tertile	All	0.875	0.707	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HLA-DQB2–LUAD (DFS)

Open the LUAD breakdown →