HLA-DQB1

Across TCGA pan-cancer cohorts, HLA-DQB1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated HLA-DQB1 data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HLA-DQB1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HLA-DQB1 expression acts as an unfavorable survival marker.

SKCM and BLCA are the cancer types where HLA-DQB1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.072	0.814	<.001	18	view →
BLCA	OS	Median	III,IV	0.149	0.655	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

HLA-DQB1–SKCM (OS)

Open the SKCM breakdown →