HLA-DQB1

Across TCGA pan-cancer cohorts, HLA-DQB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HLA-DQB1 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HLA-DQB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HLA-DQB1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where HLA-DQB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.501	0.909	<.001	39	view →
HNSC	OS	Median	IV	0.925	0.736	.007	22	view →
LUAD	DFS	Tertile	All	0.443	0.778	.019	12	view →
UCEC	DFS	Median	All	0.966	0.845	.025	6	view →
CCRCC	DFS	Quartile	III,IV	0.336	0.847	.019	5	view →
PDAC	OS	Quartile	II,III,IV	0.927	0.636	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HLA-DQB1–LSCC (DFS)

Open the LSCC breakdown →