HLA-DQB1

Across TCGA pan-cancer cohorts, HLA-DQB1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of HLA-DQB1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where HLA-DQB1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types HLA-DQB1 is over-expressed in tumor, although a few such as LSCC and COAD show the opposite, repressed pattern.

CCRCC, LSCC, and COAD are the cancer types where HLA-DQB1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-DQB1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	II,III,IV	+1.193	<.001	11	view →
LSCC	All	All	−0.528	<.001	4	view →
COAD	Female	All	−0.422	.017	3	view →
PDAC	All	All	+0.467	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

HLA-DQB1–CCRCC

Open the CCRCC breakdown →