HLA-DQA2

Across TCGA pan-cancer cohorts, HLA-DQA2 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated HLA-DQA2 data layer compared with 30 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HLA-DQA2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HLA-DQA2 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

UCEC and SKCM are the cancer types where HLA-DQA2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	All	0.888	0.298	.011	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

HLA-DQA2–UCEC (OS)

Open the UCEC breakdown →