HLA-DPA3

Across TCGA pan-cancer cohorts, HLA-DPA3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HLA-DPA3 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HLA-DPA3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated HLA-DPA3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

HNSC, ESCA, and SKCM are the cancer types where HLA-DPA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.747	0.633	.005	61	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	44	view →
SKCM	OS	Quartile	All	0.579	0.238	<.001	40	view →
LGG	OS	Median	All	0.832	0.938	<.001	33	view →
DLBC	DFS	Tertile	IV	1.000	0.245	.006	28	view →
LAML	DFS	Tertile	All	0.316	0.637	.022	22	view →
THCA	DFS	Tertile	III,IV	0.544	0.865	.012	22	view →
COAD	OS	Median	III,IV	0.785	0.580	.002	19	view →
BRCA	OS	Quartile	All	0.618	0.515	.008	19	view →
GBM	DFS	Tertile	All	0.178	0.306	.002	12	view →
CHOL	DFS	Quartile	All	0.820	0.213	.029	12	view →
LUSC	DFS	Median	III,IV	0.649	0.375	.009	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HLA-DPA3–HNSC (DFS)

Open the HNSC breakdown →