HLA-DPA3

Across TCGA pan-cancer cohorts, HLA-DPA3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HLA-DPA3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HLA-DPA3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HLA-DPA3 is over-expressed in tumor.

KIRC, HNSC, and KIRP are the cancer types where HLA-DPA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-DPA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.842	<.001	11	view →
HNSC	Male	II,III,IV	+0.425	.001	8	view →
KIRP	Male	All	+0.924	<.001	6	view →
STAD	All	All	+0.608	.001	6	view →
COAD	Male	II,III,IV	+0.700	.002	4	view →
BRCA	Female	II,III,IV	+0.466	<.001	4	view →
BLCA	Male	All	+0.716	.024	2	view →
LUAD	Female	All	+0.544	.015	2	view →
THCA	Male	III,IV	+0.432	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HLA-DPA3–KIRC

Open the KIRC breakdown →