HLA-DPA3

Across TCGA pan-cancer cohorts, HLA-DPA3 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated HLA-DPA3 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HLA-DPA3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HLA-DPA3 expression acts as an unfavorable survival marker.

HNSC and SKCM are the cancer types where HLA-DPA3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.156	0.696	.005	24	view →
SKCM	OS	Median	II,III,IV	0.380	0.744	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

HLA-DPA3–HNSC (DFS)

Open the HNSC breakdown →