HLA-DPA1

Across TCGA pan-cancer cohorts, HLA-DPA1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HLA-DPA1 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher HLA-DPA1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HLA-DPA1 expression acts as an unfavorable survival marker.

READ, BLCA, and ESCA are the cancer types where HLA-DPA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Median	All	0.059	0.845	<.001	36	view →
BLCA	OS	Median	IV	0.051	0.600	<.001	12	view →
ESCA	OS	Median	II,III,IV	0.248	0.686	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HLA-DPA1–READ (DFS)

Open the READ breakdown →