HLA-DPA1

Across TCGA pan-cancer cohorts, HLA-DPA1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HLA-DPA1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HLA-DPA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HLA-DPA1 expression acts as an unfavorable survival marker, although some lineages such as OV and PDAC show a favorable association.

COAD, OV, and CCRCC are the cancer types where HLA-DPA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.826	1.000	.023	54	view →
OV	DFS	Median	All	1.000	0.837	.018	4	view →
CCRCC	DFS	Tertile	III,IV	0.499	0.860	.028	4	view →
LSCC	DFS	Tertile	II,III,IV	0.579	0.870	.036	2	view →
PDAC	DFS	Median	III,IV	0.825	0.525	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HLA-DPA1–COAD (DFS)

Open the COAD breakdown →