HLA-DMB

Across TCGA pan-cancer cohorts, HLA-DMB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HLA-DMB data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HLA-DMB mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HLA-DMB expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where HLA-DMB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	1.000	0.856	.013	16	view →
LUAD	DFS	Tertile	All	0.763	0.421	.005	13	view →
CCRCC	OS	Median	All	0.872	1.000	.038	11	view →
GBM	OS	Tertile	All	0.411	0.625	.016	7	view →
PDAC	OS	Tertile	II,III,IV	0.902	0.725	.038	2	view →
LSCC	DFS	Median	All	1.000	0.905	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HLA-DMB–UCEC (OS)

Open the UCEC breakdown →