HLA-DMB

Across TCGA pan-cancer cohorts, HLA-DMB mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of HLA-DMB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HLA-DMB mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types HLA-DMB is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.

HNSC, LSCC, and CCRCC are the cancer types where HLA-DMB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-DMB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.942	<.001	8	view →
LSCC	Male	II,III,IV	−0.914	<.001	8	view →
CCRCC	Male	II,III,IV	+0.558	.005	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

HLA-DMB–HNSC

Open the HNSC breakdown →