Across TCGA patient cohorts, HLA-C protein abundance is significantly associated with the RNA expression of many other genes, with 7,037 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-C-associated genes across cancer lineages are STAT1, HLA-A, and HLA-B. Each is linked with HLA-C in more than 7 cancer types. Because this analysis shows association rather than direction, both HLA-C-to-partner and partner-to-HLA-C results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-C→partner) and Y-score (partner→HLA-C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	STAT1 →	+1.108	+0.640	<.001	<.001	3	8
HNSC	HLA-A →	+0.820	+0.635	<.001	<.001	3	8
OV	HLA-B →	+1.523	+0.826	<.001	<.001	3	8
OV	TAP1 →	+1.291	+0.904	<.001	<.001	3	8
OV	PSMB9 →	+1.358	+0.894	<.001	<.001	3	8
HNSC	UBE2L6 →	+0.972	+0.701	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,037 associations by consensus.

Exploration

HLA-C survival (RNA) · tumor vs normal (RNA) · all HLA-C data types