Across TCGA patient cohorts, HLA-C mutation is significantly associated with the RNA expression of many other genes, with 126 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HLA-C-associated genes across cancer lineages are TXNL1P1, RN7SL447P, and SLC25A51P2. Each is linked with HLA-C in more than 2 cancer types. Because this analysis shows association rather than direction, both HLA-C-to-partner and partner-to-HLA-C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-C→partner) and Y-score (partner→HLA-C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TXNL1P1 →	+0.117	+6.008	<.001	.002	3	3
SKCM	RN7SL447P →	+0.271	+5.970	<.001	.002	3	2
BLCA	SLC25A51P2 →	+0.029	+4.147	<.001	.009	3	2
HNSC	LINC01677 →	+0.083	+5.182	<.001	.007	3	2
HNSC	FAM106DP →	+0.127	+5.368	<.001	.005	3	2
UCEC	RNU7-41P →	+0.917	+4.748	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 126 associations by consensus.

Exploration

HLA-C survival (RNA) · tumor vs normal (RNA) · all HLA-C data types