HKDC1

Across TCGA pan-cancer cohorts, HKDC1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of HKDC1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HKDC1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types HKDC1 is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

COAD, LUAD, and CCRCC are the cancer types where HKDC1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HKDC1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+0.940	<.001	8	view →
LUAD	Female	All	+0.929	<.001	8	view →
CCRCC	Female	III,IV	−0.585	.015	4	view →
HNSC	All	III,IV	−0.191	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

HKDC1–COAD

Open the COAD breakdown →