HKDC1

Across TCGA pan-cancer cohorts, HKDC1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HKDC1 data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HKDC1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HKDC1 expression acts as an unfavorable survival marker, although some lineages such as LGG and READ show a favorable association.

ACC, LUSC, and LGG are the cancer types where HKDC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	II,III,IV	0.618	1.000	.001	50	view →
LUSC	OS	Quartile	All	0.684	0.835	<.001	45	view →
LGG	DFS	Median	All	0.474	0.327	<.001	37	view →
LIHC	OS	Quartile	All	0.592	0.777	.001	35	view →
UVM	OS	Median	III,IV	0.240	0.836	.001	32	view →
READ	OS	Median	II,III,IV	0.985	0.852	.002	31	view →
ESCA	OS	Tertile	All	0.489	1.000	.008	24	view →
SCLC	DFS	Quartile	III,IV	0.733	0.288	.004	23	view →
THYM	OS	Median	II,III,IV	0.960	0.675	.001	22	view →
KIRC	DFS	Tertile	II,III,IV	0.387	0.699	.008	20	view →
SKCM	DFS	Tertile	IV	0.790	0.176	.013	18	view →
LUAD	DFS	Tertile	III,IV	0.236	0.574	.025	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HKDC1–ACC (OS)

Open the ACC breakdown →