HKDC1

Across TCGA patient cohorts, HKDC1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HKDC1-associated genes across cancer lineages are eEF2, ATM, and TSC1. Each is linked with HKDC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HKDC1-to-partner and partner-to-HKDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by HKDC1-low versus HKDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HKDC1→partner) and Y-score (partner→HKDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.276	+1.184	.009	.022	3	3
COAD	ATM →	-0.727	-3.321	<.001	.009	3	3
COAD	TSC1 →	-0.511	-3.450	<.001	.005	3	3
COAD	CDK1 →	+0.203	+2.330	.013	.020	2	3
SKCM	E-Cadherin →	-0.959	-2.222	.009	.010	3	2
UCEC	EGFR_pY1068 →	-0.205	-1.392	.006	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

eEF2 by HKDC1 expression — UCEC

Explore this box plot interactively →