HKDC1

Across TCGA cell cohorts, HKDC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,973 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible HKDC1-associated GO terms across cancer lineages are Negative regulation of Rho protein signal transduction, Canonical NF-kappaB signal transduction, and Hyperosmotic response. Each is linked with HKDC1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HKDC1-to-partner and partner-to-HKDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Rho protein signal transduction grouped by HKDC1-low versus HKDC1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HKDC1→partner) and Y-score (partner→HKDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of Rho protein signal transduction →	+0.210	+1.202	<.001	.009	3	10
LIVER	Canonical NF-kappaB signal transduction →	+0.087	+3.111	.006	.007	3	9
LUNG_NSCLC_LUAD	Hyperosmotic response →	+0.096	+1.750	.003	.003	3	8
SOFT_TISSUE	Regulation of sodium ion transmembrane transport →	+0.099	+0.808	<.001	.004	3	8
STOMACH	Positive regulation of protein localization to cell periphery →	+0.099	+2.500	.001	.001	3	8
LUNG_NSCLC_LUSC	Renal system process →	+0.117	+2.931	.004	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,973 associations by consensus.

Negative regulation of Rho protein signal transduction by HKDC1 expression — BONE

Explore this box plot interactively →