HKDC1

Across TCGA cell cohorts, HKDC1 mutation is significantly associated with the RNA expression of many other genes, with 227 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HKDC1-associated genes across cancer lineages are NPY2R, SIGLECL1, and GRSF1. Each is linked with HKDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HKDC1-to-partner and partner-to-HKDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPY2R grouped by HKDC1-low versus HKDC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HKDC1→partner) and Y-score (partner→HKDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NPY2R →	+0.003	+2.824	<.001	.001	3	2
BREAST	SIGLECL1 →	+0.020	+4.781	<.001	.003	3	2
BLOOD_Leukemia	GRSF1 →	+0.471	+3.351	.005	.003	3	2
BLOOD_Leukemia	ZC3H10 →	+0.388	+3.214	.006	.006	3	2
BLOOD_Leukemia	MIS12 →	+0.725	+3.351	.001	.003	3	2
BLOOD_Leukemia	KCNAB3 →	+0.997	+3.351	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 227 associations by consensus.

NPY2R by HKDC1 expression — LARGE_INTESTINE

Explore this box plot interactively →