HK2

Across TCGA patient cohorts, HK2 mutation is significantly associated with the RNA expression of many other genes, with 3,270 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HK2-associated genes across cancer lineages are MTCYBP45, INO80B-WBP1, and H2AC14. Each is linked with HK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HK2-to-partner and partner-to-HK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCYBP45 grouped by HK2-low versus HK2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HK2→partner) and Y-score (partner→HK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MTCYBP45 →	+0.104	+3.027	<.001	.004	3	2
UCEC	INO80B-WBP1 →	+0.100	+2.577	<.001	<.001	3	2
UCEC	H2AC14 →	+0.564	+1.864	<.001	.004	3	2
LIHC	CDH12P1 →	+0.086	+5.169	<.001	.002	3	2
LIHC	RN7SL460P →	+0.136	+4.447	<.001	.001	3	2
LIHC	EEF1E1-BLOC1S5 →	+0.035	+4.149	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,270 associations by consensus.

MTCYBP45 by HK2 expression — CESC

Explore this box plot interactively →