HK2

Across TCGA pan-cancer cohorts, HK2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HK2 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HK2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HK2 expression acts as an unfavorable survival marker, although some lineages such as LAML and ACC show a favorable association.

KIRP, KICH, and LGG are the cancer types where HK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.894	0.968	.001	92	view →
KICH	DFS	Tertile	III,IV	0.385	1.000	.007	60	view →
LGG	OS	Median	All	0.344	0.563	<.001	53	view →
LUAD	DFS	Median	All	0.736	0.842	<.001	47	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	33	view →
LIHC	OS	Quartile	All	0.550	0.726	.002	30	view →
CESC	OS	Median	All	0.485	0.680	<.001	30	view →
LAML	DFS	Median	All	0.495	0.263	.001	24	view →
PAAD	DFS	Quartile	All	0.310	0.530	.003	23	view →
MESO	DFS	Quartile	III,IV	0.257	0.452	.015	21	view →
UCS	DFS	Quartile	III,IV	0.153	0.604	.001	16	view →
ACC	OS	Tertile	All	0.906	0.327	.010	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HK2–KIRP (OS)

Open the KIRP breakdown →