HK2

Across TCGA patient cohorts, HK2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HK2-associated genes across cancer lineages are ATM, IGFBP2, and MEK1. Each is linked with HK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HK2-to-partner and partner-to-HK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HK2-low versus HK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HK2→partner) and Y-score (partner→HK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.324	-1.736	.039	.007	3	3
UCEC	IGFBP2 →	-0.667	-1.736	.003	.007	3	2
UCEC	MEK1 →	+0.353	+2.584	.005	.001	3	2
UCEC	Notch1 →	+0.160	+2.070	.001	.001	3	2
UCEC	PCNA →	+0.221	+2.070	.003	.001	3	2
UCEC	Rad50 →	-0.275	-2.687	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ATM by HK2 expression — UCEC

Explore this box plot interactively →