HK2

Across TCGA cell cohorts, HK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,363 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HK2-associated GO terms across cancer lineages are Fructose 6-phosphate metabolic process, Glucose 6-phosphate metabolic process, and Pyruvate metabolic process. Each is linked with HK2 in more than 12 cancer types. Because this analysis shows association rather than direction, both HK2-to-partner and partner-to-HK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fructose 6-phosphate metabolic process grouped by HK2-low versus HK2-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HK2→partner) and Y-score (partner→HK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Fructose 6-phosphate metabolic process →	+0.166	+1.663	<.001	<.001	3	13
URINARY_TRACT	Glucose 6-phosphate metabolic process →	+0.112	+1.228	<.001	<.001	3	11
CNS	Pyruvate metabolic process →	+0.088	+1.468	<.001	<.001	3	11
LUNG_NSCLC_LUAD	Maintenance of protein location in mitochondrion →	+0.212	+2.006	<.001	<.001	3	10
LARGE_INTESTINE	Positive regulation of autophagy of mitochondrion →	+0.082	+0.789	<.001	.005	3	10
LUNG_NSCLC_LUAD	Monosaccharide catabolic process →	+0.114	+1.505	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,363 associations by consensus.

Fructose 6-phosphate metabolic process by HK2 expression — BLOOD_Lymphoma

Explore this box plot interactively →