HK2

Across TCGA cell cohorts, HK2 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HK2-associated genes across cancer lineages are ZNF490, C4orf47, and OR11H6. Each is linked with HK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HK2-to-partner and partner-to-HK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF490 grouped by HK2-low versus HK2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HK2→partner) and Y-score (partner→HK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF490 →	+0.494	+3.215	.002	.009	3	1
LARGE_INTESTINE	C4orf47 →	+0.455	+3.371	<.001	.004	3	1
CNS	OR11H6 →	+0.018	+4.321	<.001	.009	3	1
CNS	WFDC10A →	+0.166	+4.315	<.001	.006	3	1
CNS	FCAR →	+0.053	+4.472	<.001	.004	3	1
CNS	CYP2A13 →	+0.032	+5.044	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ZNF490 by HK2 expression — LARGE_INTESTINE

Explore this box plot interactively →