HJURP

Across TCGA pan-cancer cohorts, HJURP Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HJURP data layer compared with 31 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher HJURP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HJURP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, KIRC, and LGG are the cancer types where HJURP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.068	0.977	<.001	24	view →
KIRC	OS	Median	All	0.127	0.874	<.001	12	view →
LGG	OS	Median	All	0.325	0.814	<.001	12	view →
UCEC	DFS	Median	III,IV	1.000	0.538	.035	12	view →
BLCA	OS	Median	III,IV	0.164	0.579	.010	9	view →
LUSC	OS	Median	All	0.176	0.724	.018	6	view →
LUAD	OS	Median	II,III,IV	0.171	0.750	.002	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HJURP–THYM (OS)

Open the THYM breakdown →