HJURP

Across TCGA patient cohorts, HJURP mutation is significantly associated with the RNA expression of many other genes, with 4,895 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HJURP-associated genes across cancer lineages are PLS3-AS1, CHASERR, and ZNHIT3. Each is linked with HJURP in more than 1 cancer types. Because this analysis shows association rather than direction, both HJURP-to-partner and partner-to-HJURP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLS3-AS1 grouped by HJURP-low versus HJURP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HJURP→partner) and Y-score (partner→HJURP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLS3-AS1 →	+0.192	+1.968	.001	<.001	3	2
UCEC	CHASERR →	+0.490	+2.695	<.001	<.001	3	2
UCEC	ZNHIT3 →	+0.515	+2.557	<.001	<.001	3	2
UCEC	TAF9 →	+0.661	+2.536	<.001	<.001	3	2
UCEC	NOL12 →	+0.460	+2.254	<.001	<.001	3	2
UCEC	FRG1HP →	+0.604	+2.568	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,895 associations by consensus.

PLS3-AS1 by HJURP expression — UCEC

Explore this box plot interactively →