HJURP

Across TCGA patient cohorts, HJURP mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HJURP-associated genes across cancer lineages are Di-Ras3, Caspase-8, and FASN. Each is linked with HJURP in more than 2 cancer types. Because this analysis shows association rather than direction, both HJURP-to-partner and partner-to-HJURP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by HJURP-low versus HJURP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HJURP→partner) and Y-score (partner→HJURP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.146	-2.893	.003	.001	3	3
UCEC	Caspase-8 →	-0.263	-2.523	.002	<.001	3	2
UCEC	FASN →	+0.435	+1.584	.001	.034	3	2
UCEC	Notch1 →	+0.177	+2.920	<.001	<.001	3	2
UCEC	Akt_pT308 →	+0.432	+2.321	.044	.033	3	2
UCEC	PKC-delta_pS664 →	-0.099	-2.584	.015	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Di-Ras3 by HJURP expression — UCEC

Explore this box plot interactively →