HJURP

Across TCGA cell cohorts, HJURP mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HJURP-associated genes across cancer lineages are ANKRD33, SLC4A1, and DMRTC2. Each is linked with HJURP in more than 1 cancer types. Because this analysis shows association rather than direction, both HJURP-to-partner and partner-to-HJURP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD33 grouped by HJURP-low versus HJURP-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HJURP→partner) and Y-score (partner→HJURP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ANKRD33 →	+0.006	+5.643	<.001	.002	3	2
SKIN	SLC4A1 →	+0.293	+3.938	<.001	.005	3	2
OESOPHAGUS	DMRTC2 →	+0.006	+4.906	<.001	.006	3	1
CNS	OR1L4 →	+0.234	+4.643	<.001	.003	3	1
CNS	KRTAP5-11 →	+0.041	+4.321	<.001	.009	3	1
CNS	OR11H12 →	+0.089	+4.315	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ANKRD33 by HJURP expression — BLOOD_Lymphoma

Explore this box plot interactively →