HIVEP3

Across TCGA patient cohorts, HIVEP3 mutation is significantly associated with the RNA expression of many other genes, with 6,098 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIVEP3-associated genes across cancer lineages are SLC19A3, SHROOM4, and NPR1. Each is linked with HIVEP3 in more than 5 cancer types. Because this analysis shows association rather than direction, both HIVEP3-to-partner and partner-to-HIVEP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC19A3 grouped by HIVEP3-low versus HIVEP3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIVEP3→partner) and Y-score (partner→HIVEP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SLC19A3 →	-1.037	-3.305	.008	.009	3	6
STAD	SHROOM4 →	-0.641	-2.502	.001	.001	3	5
UCEC	NPR1 →	-0.725	-1.356	<.001	<.001	3	5
UCEC	RAD51 →	+0.683	+1.595	<.001	<.001	3	5
BLCA	IL1R1 →	-0.925	-3.542	<.001	.002	3	5
STAD	F10 →	-1.077	-2.469	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,098 associations by consensus.

SLC19A3 by HIVEP3 expression — STAD

Explore this box plot interactively →