HIVEP3

Across TCGA patient cohorts, HIVEP3 mutation is significantly associated with the total protein of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIVEP3-associated genes across cancer lineages are Cyclin-B1, GAPDH, and c-Kit. Each is linked with HIVEP3 in more than 4 cancer types. Because this analysis shows association rather than direction, both HIVEP3-to-partner and partner-to-HIVEP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by HIVEP3-low versus HIVEP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIVEP3→partner) and Y-score (partner→HIVEP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.552	+1.392	<.001	<.001	3	5
COAD	GAPDH →	+0.519	+2.182	.018	.033	3	4
STAD	c-Kit →	-0.333	-2.584	.004	.009	3	4
STAD	HSP70 →	-0.589	-2.999	.001	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.160	-1.784	<.001	<.001	3	3
STAD	PCNA →	+0.252	+3.169	.019	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

Cyclin-B1 by HIVEP3 expression — UCEC

Explore this box plot interactively →