HIRIP3

Across TCGA patient cohorts, HIRIP3 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIRIP3-associated genes across cancer lineages are eIF4E, MEK1, and STAT3_pY705. Each is linked with HIRIP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HIRIP3-to-partner and partner-to-HIRIP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by HIRIP3-low versus HIRIP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIRIP3→partner) and Y-score (partner→HIRIP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.206	+3.459	.025	.005	3	1
UCEC	MEK1 →	+0.481	+3.321	.002	.010	3	1
UCEC	STAT3_pY705 →	-0.284	-2.311	.013	.034	3	1
UCEC	Caspase-8 →	-0.261	-2.432	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

eIF4E by HIRIP3 expression — UCEC

Explore this box plot interactively →