HIRIP3

Across TCGA pan-cancer cohorts, HIRIP3 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of HIRIP3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HIRIP3 RNA is repressed in tumor relative to normal tissue. In most cancer types HIRIP3 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LIHC, and HNSC are the cancer types where HIRIP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HIRIP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	−0.463	<.001	11	view →
LIHC	Male	All	+0.887	<.001	8	view →
HNSC	Male	III,IV	+0.528	<.001	8	view →
KIRC	All	All	+0.335	<.001	8	view →
LUAD	All	All	−0.542	<.001	7	view →
UCEC	All	All	−0.826	<.001	6	view →
KIRP	All	IV	+0.479	<.001	6	view →
KICH	All	All	−0.568	<.001	4	view →
STAD	All	II,III,IV	+0.461	.032	4	view →
LUSC	All	All	−0.300	.019	3	view →
BRCA	All	All	+0.269	.011	3	view →
CHOL	All	All	+0.794	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

HIRIP3–THCA

Open the THCA breakdown →