HIRAP1

Across TCGA patient cohorts, HIRAP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,904 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HIRAP1-associated GO terms across cancer lineages are Positive regulation of macroautophagy, Negative regulation of extrinsic apoptotic signaling pathway, and Response to alcohol. Each is linked with HIRAP1 in more than 8 cancer types. Because this analysis shows association rather than direction, both HIRAP1-to-partner and partner-to-HIRAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of macroautophagy grouped by HIRAP1-low versus HIRAP1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIRAP1→partner) and Y-score (partner→HIRAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of macroautophagy →	+0.102	+0.087	<.001	<.001	3	9
ESCA	Negative regulation of extrinsic apoptotic signaling pathway →	+0.097	+0.063	<.001	<.001	3	8
STAD	Response to alcohol →	+0.074	+0.080	<.001	<.001	3	8
STAD	Sulfur compound biosynthetic process →	+0.078	+0.100	<.001	<.001	3	8
STAD	Obsolete positive regulation of mitochondrion organization →	+0.093	+0.086	<.001	<.001	3	8
ESCA	RNA methylation →	+0.102	+0.115	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,904 associations by consensus.

Positive regulation of macroautophagy by HIRAP1 expression — STAD

Explore this box plot interactively →