Across TCGA pan-cancer cohorts, HIRAP1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of HIRAP1’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where HIRAP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HIRAP1 is over-expressed in tumor.
THCA are the cancer types where HIRAP1 tumor–normal differential expression is most reproducible.