HIRA

Across TCGA pan-cancer cohorts, HIRA Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated HIRA data layer compared with 26 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher HIRA Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HIRA expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KICH, COAD, and SCLC are the cancer types where HIRA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.025	0.904	<.001	36	view →
COAD	DFS	Median	III,IV	0.130	0.616	.006	17	view →
SCLC	OS	Median	All	0.055	0.708	<.001	12	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
UCEC	DFS	Median	All	0.886	0.613	.031	6	view →
SKCM	DFS	Median	II,III,IV	0.329	0.595	.030	5	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
ESCA	DFS	Median	II,III,IV	0.149	0.522	.047	3	view →
LUSC	OS	Median	II,III,IV	0.238	0.615	.042	3	view →
LUAD	OS	Median	All	0.188	0.670	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

HIRA–KICH (DFS)

Open the KICH breakdown →