HIRA

Across TCGA pan-cancer cohorts, HIRA RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HIRA’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HIRA RNA is repressed in tumor relative to normal tissue. In most cancer types HIRA is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, STAD, and COAD are the cancer types where HIRA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HIRA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.797	<.001	11	view →
STAD	Male	II,III,IV	+1.013	<.001	10	view →
COAD	Female	All	+0.608	<.001	10	view →
HNSC	Male	III,IV	+0.823	<.001	9	view →
LIHC	All	III,IV	+0.767	<.001	9	view →
KIRP	All	III,IV	−0.518	<.001	9	view →
LUSC	Male	II,III,IV	+0.587	<.001	5	view →
KIRC	Male	II,III,IV	−0.293	.002	4	view →
BRCA	Female	II,III,IV	−0.171	.007	4	view →
CHOL	Male	All	+1.658	<.001	3	view →
READ	All	III,IV	+0.875	.035	2	view →
PRAD	All	All	+0.302	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HIRA–THCA

Open the THCA breakdown →