HIRA

Across TCGA pan-cancer cohorts, HIRA mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HIRA data layer compared with 26 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HIRA mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HIRA expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where HIRA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.948	0.723	.001	39	view →
CCRCC	DFS	Median	II,III,IV	0.813	0.451	.001	26	view →
HNSC	OS	Median	II,III,IV	0.632	0.826	.013	14	view →
PDAC	OS	Quartile	II,III,IV	0.701	1.000	.014	12	view →
OV	DFS	Tertile	All	1.000	0.627	.036	4	view →
UCEC	DFS	Quartile	III,IV	1.000	0.310	.027	4	view →
LUAD	DFS	Tertile	II,III,IV	0.819	0.846	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HIRA–LSCC (OS)

Open the LSCC breakdown →