HIRA

Across TCGA cell cohorts, HIRA RNA expression is significantly associated with the go_rna of many other GO terms, with 5,055 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HIRA-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cellular anatomical structure, Symbiont-mediated disruption of host anatomical structure, and Negative regulation of chromosome condensation. Each is linked with HIRA in more than 17 cancer types. Because this analysis shows association rather than direction, both HIRA-to-partner and partner-to-HIRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cellular anatomical structure grouped by HIRA-low versus HIRA-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIRA→partner) and Y-score (partner→HIRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Symbiont-mediated disruption of host cellular anatomical structure →	+0.156	+0.848	<.001	<.001	3	18
LUNG_SCLC	Symbiont-mediated disruption of host anatomical structure →	+0.156	+0.848	<.001	<.001	3	18
SOFT_TISSUE	Negative regulation of chromosome condensation →	+0.160	+0.687	<.001	<.001	3	18
BONE	DNA replication-dependent chromatin assembly →	+0.138	+0.817	<.001	<.001	3	17
LUNG_SCLC	Transcription elongation-coupled chromatin remodeling →	+0.139	+0.649	<.001	.001	3	17
BONE	Regulation of chromatin organization →	+0.093	+0.740	.002	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,055 associations by consensus.

Symbiont-mediated disruption of host cellular anatomical structure by HIRA expression — LUNG_SCLC

Explore this box plot interactively →