HIRA

Across TCGA cell cohorts, HIRA mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HIRA-associated genes across cancer lineages are KLF18, C3orf85, and DGAT2L6. Each is linked with HIRA in more than 1 cancer types. Because this analysis shows association rather than direction, both HIRA-to-partner and partner-to-HIRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLF18 grouped by HIRA-low versus HIRA-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIRA→partner) and Y-score (partner→HIRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	KLF18 →	+0.006	+5.000	<.001	.005	3	2
BLOOD_Myeloma	C3orf85 →	+0.103	+4.807	<.001	.006	3	1
OESOPHAGUS	DGAT2L6 →	+0.006	+4.906	<.001	.006	3	1
KIDNEY	NPVF →	+0.020	+5.000	<.001	.005	3	1
KIDNEY	GLYATL3 →	+0.043	+5.000	<.001	.005	3	1
BREAST	RBMY1A1 →	+0.006	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

KLF18 by HIRA expression — KIDNEY

Explore this box plot interactively →