HIPK4

Across TCGA patient cohorts, HIPK4 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,378 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HIPK4-associated proteins across cancer lineages are RAPGEF2_S960, MYBBP1A_S1267, and PLD3. Each is linked with HIPK4 in more than 3 cancer types. Because this analysis shows association rather than direction, both HIPK4-to-partner and partner-to-HIPK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HIPK4 versus RAPGEF2_S960 in GBM, with a Pearson correlation of 0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK4→partner) and Y-score (partner→HIPK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RAPGEF2_S960 →	+0.376	+0.438	<.001	<.001	3	4
GBM	MYBBP1A_S1267 →	-0.380	-0.417	<.001	<.001	3	3
HNSC	PLD3 →	+0.353	+0.178	<.001	.007	3	3
CCRCC	TNS2_S931 →	+0.523	+0.122	<.001	.002	3	3
GBM	RARS1 →	-0.181	-0.360	<.001	<.001	3	3
GBM	TMOD2 →	+0.452	+0.478	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,378 associations by consensus.

HIPK4 vs RAPGEF2_S960 — GBM

Explore this scatter interactively →