HIPK4

Across TCGA pan-cancer cohorts, HIPK4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HIPK4 data layer compared with 3 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher HIPK4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HIPK4 expression acts as an unfavorable survival marker, although some lineages such as UCS and THCA show a favorable association.

OV, ACC, and UCEC are the cancer types where HIPK4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	All	0.774	0.901	<.001	82	view →
ACC	DFS	Median	All	0.235	0.657	<.001	61	view →
UCEC	OS	Quartile	III,IV	0.459	0.727	.007	52	view →
UCS	DFS	Quartile	II,III,IV	0.807	0.139	<.001	48	view →
THCA	DFS	Median	All	0.895	0.749	<.001	47	view →
BRCA	OS	Quartile	III,IV	0.936	0.742	.001	47	view →
MESO	OS	Tertile	IV	0.897	0.395	.004	41	view →
SARC	DFS	Median	All	0.599	0.421	<.001	41	view →
LUAD	DFS	Median	All	0.738	0.836	<.001	32	view →
READ	OS	Median	All	0.851	0.969	.008	30	view →
CHOL	DFS	Median	All	0.858	0.128	.002	21	view →
THYM	DFS	Median	II,III,IV	0.897	0.582	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HIPK4–OV (OS)

Open the OV breakdown →