HIPK4

Across TCGA patient cohorts, HIPK4 mutation is significantly associated with the RNA expression of many other genes, with 5,055 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIPK4-associated genes across cancer lineages are TRAJ53, RN7SL134P, and RAD23A. Each is linked with HIPK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HIPK4-to-partner and partner-to-HIPK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ53 grouped by HIPK4-low versus HIPK4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK4→partner) and Y-score (partner→HIPK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRAJ53 →	+0.747	+5.148	<.001	.008	3	2
UCEC	RN7SL134P →	+0.081	+1.741	.002	.004	3	2
UCEC	RAD23A →	+0.354	+3.065	.004	<.001	3	2
UCEC	MIGA1 →	+0.363	+2.042	.002	.004	3	2
UCEC	CUEDC1 →	+0.694	+1.900	<.001	<.001	3	2
UCEC	NOMO2 →	+0.546	+2.928	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,055 associations by consensus.

TRAJ53 by HIPK4 expression — BRCA

Explore this box plot interactively →