HIPK4

Across TCGA cell cohorts, HIPK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,221 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HIPK4-associated GO terms across cancer lineages are Response to starvation, Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, and Anatomical structure maturation. Each is linked with HIPK4 in more than 8 cancer types. Because this analysis shows association rather than direction, both HIPK4-to-partner and partner-to-HIPK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to starvation grouped by HIPK4-low versus HIPK4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK4→partner) and Y-score (partner→HIPK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Response to starvation →	+0.049	+0.075	<.001	.001	2	9
LARGE_INTESTINE	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.087	+0.076	<.001	.002	3	8
BREAST	Anatomical structure maturation →	-0.044	-0.095	.001	<.001	3	8
SOFT_TISSUE	Regulation of cytokine production involved in immune response →	-0.079	-0.193	<.001	<.001	3	7
URINARY_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.152	+0.054	.007	.006	3	7
BREAST	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.129	+0.085	.006	.005	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,221 associations by consensus.

Response to starvation by HIPK4 expression — LARGE_INTESTINE

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