HIPK4

Across TCGA cell cohorts, HIPK4 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HIPK4-associated genes across cancer lineages are GPR42, TGM6, and TEKT1. Each is linked with HIPK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HIPK4-to-partner and partner-to-HIPK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR42 grouped by HIPK4-low versus HIPK4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK4→partner) and Y-score (partner→HIPK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR42 →	+0.016	+4.887	<.001	.009	3	1
SKIN	TGM6 →	+0.028	+3.930	<.001	.003	3	1
SKIN	TEKT1 →	+0.077	+3.930	<.001	.003	3	1
SKIN	CYSLTR1 →	+0.486	+4.054	<.001	.004	3	1
SKIN	OR1L1 →	+0.014	+4.437	<.001	.004	3	1
SKIN	FOXI2 →	+0.005	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GPR42 by HIPK4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →