HIPK3

Across TCGA patient cohorts, HIPK3 protein abundance is significantly associated with the RNA expression of many other genes, with 6,034 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HIPK3-associated genes across cancer lineages are PNRC2P1, AKR1B10, and MTHFSD. Each is linked with HIPK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HIPK3-to-partner and partner-to-HIPK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HIPK3 versus PNRC2P1 in LUAD, with a Pearson correlation of -0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK3→partner) and Y-score (partner→HIPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PNRC2P1 →	-0.578	-0.493	.006	.007	3	2
HNSC	AKR1B10 →	-3.191	-0.918	.005	.003	3	2
LSCC	MTHFSD →	-0.518	-0.627	<.001	.002	3	2
HNSC	ZNF319 →	-1.020	-0.918	.008	.003	3	2
HNSC	MUC17 →	+0.115	+0.973	.002	.007	3	2
HNSC	CORO1B →	-1.794	-1.192	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,034 associations by consensus.

HIPK3 vs PNRC2P1 — LUAD

Explore this scatter interactively →