HIPK3

Across TCGA pan-cancer cohorts, HIPK3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HIPK3’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where HIPK3 RNA is repressed in tumor relative to normal tissue. In most cancer types HIPK3 is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LUAD, and THCA are the cancer types where HIPK3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HIPK3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−1.338	<.001	10	view →
LUAD	Female	II,III,IV	−0.725	<.001	7	view →
THCA	Female	All	−0.624	<.001	7	view →
UCEC	All	All	−1.601	<.001	6	view →
KICH	Female	All	−1.168	<.001	6	view →
LUSC	All	II,III,IV	−0.651	<.001	6	view →
BRCA	Female	All	−0.522	<.001	6	view →
KIRC	Male	III,IV	−0.359	.010	6	view →
COAD	All	All	−0.374	.015	3	view →
READ	All	All	−0.919	.004	2	view →
CHOL	All	All	+0.877	.011	2	view →
KIRP	Male	All	−0.489	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HIPK3–BLCA

Open the BLCA breakdown →